Limidax XR
Citrus aurantium

Found in Limidax as: Synephrine Caprylate.

The Research and Science Behind Microencapsulated Caffeine

Updated on March 23, 2015

Synephrine Caprylate is a protoalkaloid compound and trace amine that can be produced in the human body or can be found in high levels in Citrus aurantium (bitter orange). Synephrine Caprylate is highly effectively utilized within Limidax.



Synephrine, Green Tea Extract, and Caffeine: Limidax Achieves Synergy

Confusion and controversy exist regarding the cardiovascular effects of dietary supplements containing caffeine and Citrus aurantium (bitter orange) extract. Fourteen female and nine male subjects volunteered in a randomized, placebo-controlled, crossover, double-blind designed study to investigate the cardiovascular effects of a product containing caffeine, bitter orange extract (synephrine) and green tea extract with regulation of several important physiological functions.

No effects of the dietary supplement on heart rate, systolic and diastolic blood pressure or mean arterial pressure were observed. The results of this study indicate that ingestion of a product containing bitter orange extract, caffeine and green tea extract does not lead to increased cardiovascular stress.

Limidax XR has all three ingredients in order to provide maximum benefits in both the short-term and long-term without the worry of side-effects. You can read the full study yourself through The U.S. National Library of Medicine



  1. Please read the research for yourself: A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Authors: Stohs SJ, Preuss HG, Shara M. The Direct Link to the Study is: http://www.ncbi.nlm.nih.gov/pubmed/22991491
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us: support@limidax.com

  2. Please read the research for yourself: p-Synephrine: a novel agonist for neuromedin U2 receptor. Authors: Zheng X, Guo L, Wang D, Deng X. The Direct Link to the Study is: http://www.ncbi.nlm.nih.gov/pubmed/24598981
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us: support@limidax.com

  3. Please read the research for yourself: Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. Authors: Seifert JG, Nelson A, Devonish J, Burke ER, Stohs SJ. The Direct Link to the Study is: http://www.ncbi.nlm.nih.gov/pubmed/21448304
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us: support@limidax.com


Human Clinical Studies involving Citrus aurantium extract and primary protoalkaloid synephrine

Synephrine alone as well as in combination products was shown to increase metabolic rate and energy.

The change of effect were statistically significant (p-value < 0.05). This conclusion was reached as results of over 20 studies involving a total of approximately 360 subjects. You can read the full study yourself through The U.S. National Library of Medicine

Synephrine: A Novel for Neuromedin U2 Receptor

In the brain, Neuromedin U2 receptor (NMU2R) is prominent in the hypothalamic regions and is known to be associated with regulation of several important physiological functions .

In NMU2R activating ability experiments, p-synephrine was found binding to NMU2R with high efficacy and potency, with researchers agreeing that Synephrine has important value. You can read the full study yourself through The U.S. National Library of Medicine