Limidax XR

Found in Limidax as: Microencapsulated Phenethylamine HCL.

The Research and Science Behind Phenethylamine

Updated on March 23, 2015

Phenethylamine, also known as Phenylethylamine (or PEA for short), is an organic compound, a natural monoamine alkaloid, and a trace amine. PEA has a history of usage for cognitive enhancement, mood improvement, and as a concentration aid. We use Microencapsulation Technology to release the Phenethylamine in Limidax over an extended period of time (XR = extended release), and not all at once. This way, you do NOT experience a massive burst followed by a major downfall in the positive cognitive effects in a short-period of time. The ingredient has a very successful track record of scientific and clinical studies showing that it may have functional benefits from short-term to long-term use. Phenethylamine HCL is in our study pill as a nootropic, because research has shown that it may help support increased brain function, focus, attention, mental performance, and stamina on demanding tasks.

Why Phenethylamine HCL is in our Limidax Extended Concentration Proprietary Blend

Limidax XR microencapsulated phenethylamine is a one-of-a-kind ingredient delivery system, designed to provide a sustained benefits, ideal for studying and completing tasks. When allowed across the blood brain barrier, phenylethylamine HCL has a profound effect neurologically. However, phenylethylamine HCL has a very short half life within humans when contact is made prior to the blood brain barrier. A five- to 15-minute half life is all that is usually observed within human beings as phenylethylamine HCL is very quickly metabolized in the body by the monoamine oxidase A, monoamine oxidase B, aldehyde dehydrogenase and dopamine betahydroxylase enzymes present. Limidax XR has addressed this issue through Microencapsulation Technology, allowing for the effects to last much longer. Phenethylamine HCL naturally occurs within the nervous systems of humans and other mammals, where it is thought to act as a type of neuromodulator. Within the human brain it causes the release of norepinephrine and dopamine, two very powerful brain chemicals involved in attention and alertness.

Limidax XR uses LIMIDAX Smart Dosing™ Microencapsulation Technology to deliver maximum focus benefits. Our innovative approach allows for a sustained release profile along with improved delivery. Our multiple targeted release points enables Limidax to start working within 30 minutes to an hour after consumption, while also lasting up to 12 hours!

Higher levels of the neurotransmitter Acetylcholine may improve memory and result in a faster speed of memory retrieval. People have reported feeling that they have deeper access to stored memories. Many users also report an increase in learning capacity and an improved or lengthened attention span. In some cases, these benefits are also accompanied by an enhanced sensory perception, particularly in terms of sight and sound.

Phenylethylamine Improves Mood and Helps Concentration

PEA acts within the emotional center of the brain, increasing motivation and physical drive, intensifying feelings, decreasing anxiety, and encouraging social and other activity. It does this by stimulating:

  • Dopamine, releasing feeling of pleasure while doing the task at hand
  • Norepinephrine, that keeps us awake and enables us to perform better
  • Acetylocholine, that improves memory and general mental activity
  • Serotonin, that controls our emotions and impulses

Microencapsulated Phenylethylamine HCL

Clinical studies indicate that phenylethylamine has both short-term and long-term benefits. For this reason it is used in supplements that are designed to slow down the many inevitable age-related memory and performance issues, as well as in supplements like Limidax, that provide a powerful short-term brain boost for studying and other intense work-related tasks.

But, there is a distinct difference between the phenylethylamine that occurs naturally in the brain, other phenylethylamine supplements in the market, and the phenylethylamine released through Limidax XR.

When phenylethylamine crosses the blood brain barrier, it has been found to have an intense neurological effect. But this lasts for a very short time - only about five to 15 minutes. However, our scientists have overcome this issue with microencapsulation technology that increases the length of time the chemical works, and it is the microencapsulated phenethylamine that is used in Limidax XR, thereby extending its effect.

How Phenylethylamine Works

Phenylethylamine activates muscarinic acetylocholine receptors (mAChRs) that use G proteins (guanine nucleotide-binding proteins) to transmit signals on the outside of cells, to the inside. Simplified, they are like molecular switches that go “on” and “off” at certain times.

G proteins were initially identified by scientists studying ways in which adrenaline stimulates cells. They found, amongst other things, that malfunctioning G protein-coupled receptors (GPCRs) are implicated in a number of diseases including cancer and depression.

In addition to mAChRs, there are other forces within the central nervous system including nicotinic receptors (nAChRs) and muscarinic cholinergic receptors. Also, it is thought that it is the higher levels of acetylocholine that directly affect memory and the ability to concentrate.

A study report on research relating to the effect of muscarinic cholinergic receptors in the hippocampus and neocortex areas of the brain was released late last year (2014). Scientists looked at basic aspects of the mAChR system, focusing on inhibitory synaptic rhythms in the hippocampus and neocortex.

Aware that mAChRs affect both network and cellular properties in the brain, they found that these receptors also mobilize endogenous cannabinoids (also known as endocannabinoids or eCBs). The eCBs, in turn, act on the main cannabinoid brain receptor (CBIR) regulating specific neurotransmittors including GABA, which balances the mind and body in times of great excitement, and which is used to treat various conditions including Attention Deficit Hyperactivity Disorder (ADHD).

Ultimately, they concluded that continued study of the mAChr system in the brain will certainly continue to bring new insight and information about many neurophysiological problems. They stated that there was “enormous promise for novel and valuable advances” that would lead to a better understanding of the mAChr regulatory system, and also to new clinical applications.

Great Book about Phenethylamine

While formal research on phenethylamine continues, probably the best (certainly most interesting) account of its effects – and those of psychoactive chemical derivatives – can be found in a legendary, partly fictitious book written by chemist Dr Alexander Shulgin and his wife Ann. Published in 1991, PiHKAL: A Chemical Love Story was never intended as a bona fide research project, but was intended to share the authors’ beliefs about the value of certain psychedelic drugs.

The title PiHKAL is the acronym for “Phenylethylamines I Have Known and Loved.” The experiences described took place over more than three decades, and the book is close to 1,000 pages in extent.

What is Phenylethylamine HCL Used for

Phenylethylamine HCL is used for many purposes, including enhancing mood, energy, and focus. It is the brain’s strongest stimulant and the chemical that gives athletes “runner’s high,” the feeling of euphoria some runners experience after a long period of exercise.

Phenylethylamine is also known as the “love drug” because it replicates the brain chemistry of a person in love – it is a compound found in both chocolate and red wine. It helps with weight loss as it stimulates the neurotransmitters that control appetite, alertness, euphoria, and feelings of attraction.

See the top phenethylamine benefits below:

Top 5 Phenethylamine Benefits:

PEA is credited with fueling the release of Acetylcholine in the brain. Acetylcholine is a neurotransmitter that is important in several brain tasks including attention span, recall, learning, memory, and even sensory awareness. In addition, it helps release b-endorphin which imitates the feeling of falling in love due to accelerating the release of large amounts of Norepinephrine and Dopamine.

Although Phenylethylamine HCL has an intense neurological effect when permitted to cross the blood-brain barrier, it only has a 5-15 minute half-life if it does not reach the blood-brain barrier due to being metabolized quickly by the body. So, this is why Limidax incorporates the Smart Dosing™ Microencapsulation Technology, in order to release the PEA over an extended period of time rather than all at once. This ensures that you will not experience a gigantic burst of energy that is quickly followed by a major decrease in positive brain power. As a brain supplement, Limidax starts working within a 30 minute to 1 hour time frame and lasts up to 12 hours, which is ideal for completing tasks, maximizing focus, and participating in intense studying sessions with productive results!

There are many benefits associated with using this supplement including the following:

Improves Memory and Concentration

Phenylethylamine releases the neurotransmitter known as Acetylcholine which promotes neuroplasticity, which is the growth and elongation of neurons. This creates brand new connections between neural synapses at a very easy and fast pace. As a result, your mind is more susceptible to changes and can quickly create new logical connections to help you with problem solving. This also helps increase your attention span, motivation, and focus for a longer period of time. In addition, people have reported that they can retrieve memories stored in long-term memory much faster. Likewise, people have noticed that they can learn a larger amount of new material in a faster amount of time. Another great benefit is that the brain chemical known as Norepinephrine is stimulated, which helps you stay awake longer in order to accomplish more.

Enhances Mood

While taking Phenethylamine, your mood is improved due to the release of Dopamine which promotes a feeling of well-being while completing the tasks that you are working on. In addition, Serotonin is released which helps control your impulses and emotions.In fact, this nootropic has been shown to drastically improve your mood, encourage social activity, and can also help reduce anxiety, and stress.

Helps Increase Metabolism

PEA may help to speed up your metabolism due to the increase in energy level, blood glucose, and blood pressure level. As a result, this means that the compound can lead to additional fat burning. This is why there are several weight loss and diet products on the market that include this substance as one of the active ingredients.

Increasing the level of PEA Metabolites

Studies indicate that increasing PEA improves attentiveness and the mental processing of information.

Heightens the Senses

All of the five senses are activated and heightened while taking Phenethylamine. Since ingesting the natural compound can raise blood pressure due to vasoconstriction, it can cause you to become extra sensitive to various stimuli and actually accentuate your thoughts and senses. You might notice that colors are much more vivid and sounds are much more pronounced. You also become much more aware of your surroundings. Likewise, since your heart rate increases, it can set in motion the typical “fight or flight” responses. 

What Does Phenylethylamine Do To You?

Phenylethylamine works like many other nootropics. Once you ingest it, it goes into your bloodstream and crosses the blood-brain barrier to get to the brain. Once it reaches the brain, it works on the neurotransmitters Norepinephrine and Dopamine.

It helps increase the production and release of these two neurotransmitters and blocks the action of transmitters that decrease their concentration. As a result, the synaptic receptors for Norepinephrine and Dopamine experience higher levels of stimulation.

Phenylethylamine is also believed to activate the functions of Acetylcholine, the brain chemical that plays a major role in cognitive processes such as learning, attention, memory formation, and recall.

How Exactly does it Work?

Phenylethylamine triggers Acetylocholine receptors which use G proteins to emit signals from the outside to the inside of cells. These G proteins are so important that science has shown that those that malfunction have been found to cause many diseases including depression and cancer. PEA also causes the brain to release larger levels of Acetylocholine which enhances concentration and memory. In addition, the Acetylocholine receptors cause endogenous cannabinoids to produce neurotransmitters such as GABA.

Sources of Phenethylamine

PEA is naturally found in both the human and mammal nervous systems. In addition, it is most often sold as a nutritional supplement in the form of Phenylethylamine HCL. Likewise, it is found in chocolate and is referred to as the “love drug” since the alkaloid is released by our brains when we experience a romantic attraction.

Phenthylamine Is The Ingredient In Chocolate That Makes You Feel Good

While chocolate contains more than 300 beneficial compounds, the most influential is Phenylethylamine. It is what makes you feel good when you eat chocolate.

This chemical, found in chocolate in small quantities, activates the nervous system and prompts the release of endorphins. Endorphins are morphine-like chemicals that trigger positive feelings in the body and help reduce pain.

Phenylethylamine also helps boost the power of dopamine, the brain chemical associated with pleasure. It acts as a powerful antidepressant and increases during periods of romance.

When you are in love, the giddy feeling you get is largely due to Phenylethylamine, which considerably increases in the brain at that time.


The half life of Phenethylamine is extremely short though. This causes individuals to need to take it multiple times during the day to maintain effects. It can also cause problems, since constantly taking the supplement multiple times can cause booms and busts that lead to negative effects. That is why you should look for high quality Phenethylamine that is Microencapsulated. Limidax contains microencapsulated phenethlyamine, so you do not need to worry about additional dietary dosages. However, if you choose not to go with Limidax, it is important to keep in mind that you should not take over 1,000 milligrams on a daily basis.

Final Comments

Phenethylamine is a powerful nootropic with several memory-enhancing benefits. Although there are certain possible side effects, the majority of them are only experienced when people do not take the recommended dosage of the supplement. The fact is that the future looks very bright for this supplement. A number of medical uses including asthma treatments and decongestants have been created as a result of using this powerful and versatile supplement. In addition, there are many other scientific discoveries that could very well be on the horizon in the not-to-distant future.

We encourage you to try out Limidax XR. Limidax contains high quality Microencapsulated Phenethylamine.

  1. Please read the research for yourself: Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex. Authors: Alger BE, Nagode DA, Tang AH. The Direct Link to the Study is:
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us:

  2. The detailed research of phenylethylamine HCL and its derivatives are documented in Alexander Shulgin's book "PiHKAL."
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us:

Cholinergic Receptors Modulate Rhythms in Hippocampus and Neocortex

Phenylethylamine increases the release of Acetylcholine. Activation of muscarinic acetylcholine (ACh) receptors (mAChRs) powerfully affects many neuronal properties as well as numerous cognitive behaviors. Small neuronal circuits constitute an intermediate level of organization between neurons and behaviors, and mAChRs affect interactions among cells that compose these circuits. By acting on the principal cannabinoid receptor of the brain, CB1R, regulate the release of certain neurotransmitters, including GABA. The scientists concluded that, "the ability of optogenetic methods to probe the many roles of ACh in rhythm generation is highlighted." You can read the full study yourself through The U.S. National Library of Medicine

Detailed Research Says: PEA HCL Boosts Cognitive Function

Phenylethylamine HCL acts to increase dopamine levels within the brain as well as block the action of dopamine transmitters. This dual action effect causes a large build up of dopamine within the brain if exposure beyond the blood brain barrier is not terminated or otherwise controlled.

When allowed across the blood brain barrier, phenylethylamine HCL has a profound effect both neurologically and as a corollary emotionally in humans. Limidax has addressed the short-half life problem of Phenylethylamine through microencapsulation technology. You can read more about Phenylethylamine HCL and its derivatives through the works of chemist Alexander Shulgin. The detailed research of phenylethylamine HCL is available for your reading pleasure .

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FDA disclosure and warning: The statements on this site have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Before starting any new diet and exercise program please check with your doctor and clear any exercise and/or diet changes with them before using Limidax XR.