Limidax XR
Phenethylamine

Found in Limidax as: Microencapsulated Phenethylamine HCL.

The Research and Science Behind Phenethylamine

Updated on March 23, 2015

Phenethylamine, also known as Phenylethylamine (or PEA for short), is an organic compound, a natural monoamine alkaloid, and a trace amine. PEA has a history of usage for cognitive enhancement, mood improvement, and as a concentration aid. We use Microencapsulation Technology to release the Phenethylamine in Limidax over an extended period of time (XR = extended release), and not all at once. This way, you do NOT experience a massive burst followed by a major downfall in the positive cognitive effects in a short-period of time. The ingredient has a very successful track record of scientific and clinical studies showing that it may have functional benefits from short-term to long-term use. Phenethylamine HCL is in our study pill as a nootropic, because research has shown that it may help support increased brain function, focus, attention, mental performance, and stamina on demanding tasks.



Why Phenethylamine HCL is in our Limidax Extended Concentration Proprietary Blend

Limidax XR microencapsulated phenethylamine is a one-of-a-kind ingredient delivery system, designed to provide a sustained benefits, ideal for studying and completing tasks. When allowed across the blood brain barrier, phenylethylamine HCL has a profound effect neurologically. However, phenylethylamine HCL has a very short half life within humans when contact is made prior to the blood brain barrier. A five- to 15-minute half life is all that is usually observed within human beings as phenylethylamine HCL is very quickly metabolized in the body by the monoamine oxidase A, monoamine oxidase B, aldehyde dehydrogenase and dopamine betahydroxylase enzymes present. Limidax XR has addressed this issue through Microencapsulation Technology, allowing for the effects to last much longer. Phenethylamine HCL naturally occurs within the nervous systems of humans and other mammals, where it is thought to act as a type of neuromodulator. Within the human brain it causes the release of norepinephrine and dopamine, two very powerful brain chemicals involved in attention and alertness.

Limidax XR uses LIMIDAX Smart Dosing™ Microencapsulation Technology to deliver maximum focus benefits. Our innovative approach allows for a sustained release profile along with improved delivery. Our multiple targeted release points enables Limidax to start working within 30 minutes to an hour after consumption, while also lasting up to 12 hours!



Higher levels of the neurotransmitter Acetylcholine may improve memory and result in a faster speed of memory retrieval. People have reported feeling that they have deeper access to stored memories. Many users also report an increase in learning capacity and an improved or lengthened attention span. In some cases, these benefits are also accompanied by an enhanced sensory perception, particularly in terms of sight and sound.



Phenylethylamine Improves Mood and Helps Concentration

PEA acts within the emotional center of the brain, increasing motivation and physical drive, intensifying feelings, decreasing anxiety, and encouraging social and other activity. It does this by stimulating:

  • Dopamine, releasing feeling of pleasure while doing the task at hand
  • Norepinephrine, that keeps us awake and enables us to perform better
  • Acetylocholine, that improves memory and general mental activity
  • Serotonin, that controls our emotions and impulses

Microencapsulated Phenylethylamine HCL

Clinical studies indicate that phenylethylamine has both short-term and long-term benefits. For this reason it is used in supplements that are designed to slow down the many inevitable age-related memory and performance issues, as well as in supplements like Limidax, that provide a powerful short-term brain boost for studying and other intense work-related tasks.

But, there is a distinct difference between the phenylethylamine that occurs naturally in the brain, other phenylethylamine supplements in the market, and the phenylethylamine released through Limidax XR.

When phenylethylamine crosses the blood brain barrier, it has been found to have an intense neurological effect. But this lasts for a very short time - only about five to 15 minutes. However, our scientists have overcome this issue with microencapsulation technology that increases the length of time the chemical works, and it is the microencapsulated phenethylamine that is used in Limidax XR, thereby extending its effect.

How Phenylethylamine Works

Phenylethylamine activates muscarinic acetylocholine receptors (mAChRs) that use G proteins (guanine nucleotide-binding proteins) to transmit signals on the outside of cells, to the inside. Simplified, they are like molecular switches that go “on” and “off” at certain times.

G proteins were initially identified by scientists studying ways in which adrenaline stimulates cells. They found, amongst other things, that malfunctioning G protein-coupled receptors (GPCRs) are implicated in a number of diseases including cancer and depression.

In addition to mAChRs, there are other forces within the central nervous system including nicotinic receptors (nAChRs) and muscarinic cholinergic receptors. Also, it is thought that it is the higher levels of acetylocholine that directly affect memory and the ability to concentrate.

A study report on research relating to the effect of muscarinic cholinergic receptors in the hippocampus and neocortex areas of the brain was released late last year (2014). Scientists looked at basic aspects of the mAChR system, focusing on inhibitory synaptic rhythms in the hippocampus and neocortex.

Aware that mAChRs affect both network and cellular properties in the brain, they found that these receptors also mobilize endogenous cannabinoids (also known as endocannabinoids or eCBs). The eCBs, in turn, act on the main cannabinoid brain receptor (CBIR) regulating specific neurotransmittors including GABA, which balances the mind and body in times of great excitement, and which is used to treat various conditions including Attention Deficit Hyperactivity Disorder (ADHD).

Ultimately, they concluded that continued study of the mAChr system in the brain will certainly continue to bring new insight and information about many neurophysiological problems. They stated that there was “enormous promise for novel and valuable advances” that would lead to a better understanding of the mAChr regulatory system, and also to new clinical applications.

Great Book about Phenethylamine

While formal research on phenethylamine continues, probably the best (certainly most interesting) account of its effects – and those of psychoactive chemical derivatives – can be found in a legendary, partly fictitious book written by chemist Dr Alexander Shulgin and his wife Ann. Published in 1991, PiHKAL: A Chemical Love Story was never intended as a bona fide research project, but was intended to share the authors’ beliefs about the value of certain psychedelic drugs.

The title PiHKAL is the acronym for “Phenylethylamines I Have Known and Loved.” The experiences described took place over more than three decades, and the book is close to 1,000 pages in extent.



  1. Please read the research for yourself: Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex. Authors: Alger BE, Nagode DA, Tang AH. The Direct Link to the Study is: http://www.ncbi.nlm.nih.gov/pubmed/25249974
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us: support@limidax.com

  2. The detailed research of phenylethylamine HCL and its derivatives are documented in Alexander Shulgin's book "PiHKAL."
    Any questions? Our neuroscientists are ready to answer your questions. Reach out to us: support@limidax.com


Cholinergic Receptors Modulate Rhythms in Hippocampus and Neocortex

Phenylethylamine increases the release of Acetylcholine. Activation of muscarinic acetylcholine (ACh) receptors (mAChRs) powerfully affects many neuronal properties as well as numerous cognitive behaviors. Small neuronal circuits constitute an intermediate level of organization between neurons and behaviors, and mAChRs affect interactions among cells that compose these circuits. By acting on the principal cannabinoid receptor of the brain, CB1R, regulate the release of certain neurotransmitters, including GABA. The scientists concluded that, "the ability of optogenetic methods to probe the many roles of ACh in rhythm generation is highlighted." You can read the full study yourself through The U.S. National Library of Medicine

Detailed Research Says: PEA HCL Boosts Cognitive Function

Phenylethylamine HCL acts to increase dopamine levels within the brain as well as block the action of dopamine transmitters. This dual action effect causes a large build up of dopamine within the brain if exposure beyond the blood brain barrier is not terminated or otherwise controlled.

When allowed across the blood brain barrier, phenylethylamine HCL has a profound effect both neurologically and as a corollary emotionally in humans. Limidax has addressed the short-half life problem of Phenylethylamine through microencapsulation technology. You can read more about Phenylethylamine HCL and its derivatives through the works of chemist Alexander Shulgin. The detailed research of phenylethylamine HCL is available for your reading pleasure .